I have a '95 Silverado with aftermarket wheels. The wheel hub bore is larger than hub on the truck. Have had no problems.
Had a '01 Ram with aftermarket wheels. Same thing, no problems. Both these trucks were/are for work and haul 1500-2000 pounds daily.
Also have a '14 Maxima with aftermarket wheels. Same deal. Wheel bore larger than hub. But, these wheels came with hub adapters that take up the space between the wheel hub and car hub. But, again, no problems.
Have also had a '82 ElCamino, '79 Chevy 1500, '83 Camaro, '91 Integra, '89 240SX, '93 Accord, and who knows what else that all had aftermarket wheels that had a larger wheel bore than the car/truck. And again, no problems.
BUT, if using spacers, I personally, would use stock wheels with the correct bore, or aftermarket with the adapters.
Reason being, spacers are aluminum and the hub is steel. Therefore, in my thinking, the steel hub where the lugs are "mounted" would be stronger than the aluminum on the spacers and handle the weight and forces better.