If you have alot of build up it will make a huge WHITE smoke cloud when you restart the engine.
It works out best to slowly suck around half the can in the engine while keeping it running.. When you have around half the can in, suck in alot and kill the engine then let it sit for 10min or so.. It may be alittle hard to start and may spit and spudder but it should idle smooth after a few min. You may need to give it alittle has to keep it running..
If you run it in the oil, do it before the oil change. Run it for alittle while(200 miles or so), then change the oil. If its time to change the spark plugs then do that after you suck the seafoam in.
Ive heard some people like to suck it through the brake booster line and some like to pour it into the TB or use another vacuum line. I like the brake booster line..