There are many different ways to service the trans,some are safe,others should be avoided at all cost.
1-A true trans flush uses chemicals and a fluid exchange machine,this is not a reverse flush and with the chemicals should be done often,at least every 30,000miles,to prevent harm.Good flush machines and the good chemicals are either made by BG or Wynns and stay away from others.These machines tie into one trans cooler line and the trans pump pumps the old fluid out while the machine pumps in new fluid at the same rate/volume,this is done in the correct direction of flow also.
2-A fluid exchange machine is like the above stated but does not use chemicals and is safe for any mileage if the correct fluid is used and no chemicals.
3-Drain and refill,you just drop the trans pan and replace the filter and refill the trans to the correct leval.Very safe at any mileage but only replaces about 1/3 of the junk fluid.
4-Reverse powerflush-------STAY AWAY at all cost,will damage any transmission regardless of the mileage.